Mesterolone france

Valproic acid was first synthesized in 1882 by Beverly S. Burton as an analogue of valeric acid , found naturally in valerian . [66] Valproic acid is a carboxylic acid , a clear liquid at room temperature. For many decades, its only use was in laboratories as a "metabolically inert" solvent for organic compounds. In 1962, the French researcher Pierre Eymard serendipitously discovered the anticonvulsant properties of valproic acid while using it as a vehicle for a number of other compounds that were being screened for antiseizure activity. He found it prevented pentylenetetrazol -induced convulsions in laboratory rats . [67] It was approved as an antiepileptic drug in 1967 in France and has become the most widely prescribed antiepileptic drug worldwide. [68] Valproic acid has also been used for migraine prophylaxis and bipolar disorder. [69]

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It is extremely toxic to bees. An . Environmental Protection Agency (EPA) study found that micrograms was enough to kill honey bees . [2] It is also extremely toxic to aquatic life with a study showing concentrations of ppb killing mysid shrimp. [2] It has increased risk of liver cancer in rats and mice in long term exposure. [2] It is capable of killing mosquitoes , [3] although remains poisonous to cats and dogs, with seizures and deaths being reported due to poisoning. [2] Specific data on concentrations or exposure is lacking.

Mesterolone france

mesterolone france

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