Resistance to ketoconazole has been observed in a number of clinical fungal isolates, including Candida albicans . Experimentally, resistance usually arises as a result of mutations in the sterol biosynthesis pathway. Defects in the sterol 5-6 desaturase enzyme reduce the toxic effects of azole inhibition of the 14-alpha demethylation step. Multidrug-resistance (MDR) genes can also play a role in reducing cellular levels of the drug. As azole antifungals all act at the same point in the sterol pathway, resistant isolates are normally cross-resistant to all members of the azole family.  
Halotestex Tablets are not grandly popular among performance enhancing athletes due to the simple reason that it only brings a few beneficial traits for most individuals which is not worth taking a risk for a compound like halotestin whose risks far outweigh the rewards. There are many more other steroids with almost similar and more benefits having less side-effects. However, it can be used by the competitive athlete or bodybuilder for enhancing aggression and push that is sometimes required to complete a brutal contest diet. Having said that, still one needs to use halotestin with utmost caution and not forget its long-term effects.
As stated, this is not a miracle steroid; a good steroid absolutely but it holds nowhere near the power of say Trenbolone that also greatly promotes hardness and lipolysis among many other traits. However, Masteron-Enanthate is far milder than Trenbolone but before you get too excited you need to understand an important fact. If you’re sitting there at 20% body-fat Masteron-Enanthate is not going to do a lot for you; to benefit from this steroid you need to be fairly lean to begin with as the effects won’t be all that noticeable unless you are. Yes, it may indeed help you lose a little fat if you are at a high percentage of body-fat but there are other things you can use and other things you can do that will be far more beneficial and far more worth your time and money. To truly benefit from the Masteron-Enanthate hormone we need to be below 8% and most will find below 6% to be even better. If we are this lean when we begin using the steroid the hardening affect brought on by both its androgenic nature and ability to have an anti-aromatase effect will be pretty close to amazing. Further, for the competitive bodybuilder looking to drop that last little bit of fat this hormone can be even more useful as Masteron may be the final ingredient missing to do just that.