Nandrolone decanoate (Deca-Durabolin) was injected intramuscularly into healthy volunteers. One group of females received one injection of 100 mg and three groups of males received one injection of 200 mg, two repeat injections of 100 mg or four repeat injections of 50 mg respectively. The serum levels of nandrolone (19-nortestosterone) were determined by radioimmunoassay and used to estimate pharmacokinetic parameters. The following pharmacokinetic parameters were found: a mean half-life of 6 days for the release of the ester from the muscular injection depot into the general circulation; a mean half-life of h for the combined processes of hydrolysis of nandrolone decanoate and of distribution and elimination of nandrolone; a mean nandrolone serum clearance of 1 X h-1 X kg-1. The half-life of hydrolysis of nandrolone decanoate in serum was of the order of one hour or less. The data are consistent with linear kinetics.
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Once we have added in the necessary testosterone, the next step is controlling the impending estrogen and progesterone activity that will result from the use of the Nandrolone hormone. This makes the use of anti- estrogens highly recommended; most will need an Aromatase Inhibitor (AI). However, if we suppress estrogenic activity too much, this can lead to complications; it can lead to sexually related side effects as well as damage cholesterol. Conversely, if we do not control estrogen and let the hormone run wild, high levels of estrogen can lead to gynecomastia , water retention and also negatively affect sexual function. Find the right balance of testosterone to estrogen and you will not have a problem when stacking Deca Durabolin.